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Synthetic Genetic Systems: A New Frontier in Genomics Research

Welcome to a deep dive into the world of molecular evolution. Dr. Steven Benner is the driving force behind some of the most groundbreaking advancements in synthetic biology, particularly through his work with Firebird Biomolecular Sciences and the Foundation for Applied Molecular Evolution (FfAME). Links below! In this video you will uncover the history and process for creating Artificially Expanded Genetic Information Systems (AEGIS). AEGIS is a groundbreaking innovation that extends the natural genetic alphabet beyond the four standard nucleotides—adenine (A), thymine (T), cytosine (C), and guanine (G)—which pair as A-T and C-G in DNA by introducing synthetic nucleotides that can form new base pairs. This expanded genetic alphabet allows for the creation of DNA molecules with properties not found in nature, which opens up a vast array of possibilities in molecular biology. In diagnostics, AEGIS-based systems can be used to detect specific sequences of nucleotides with unparalleled accuracy, leading to more sensitive and specific tests for diseases. In therapeutics, AEGIS could enable the development of novel drugs that target genetic sequences with high precision, potentially leading to more effective treatments with fewer side effects. Dr. Benner discusses the process of laboratory in vitro evolution (LIVE), also known as directed evolution, a technique that is used to mimic the process of natural selection in a controlled laboratory environment to evolve enzymes that are designed to work with AEGIS, called AEGISzymes. By evolving these enzymes in the presence of unnatural base pairs, Dr. Benner and his team have produced AEGISzymes that are optimized for their intended tasks, whether that’s replicating expanded DNA sequences, catalyzing unique reactions, or constructing synthetic biomolecules. Join us as we explore the incredible work of Dr. Steven Benner and his quest to revolutionize molecular science through the lens of evolution. Firebird Biomolecular Sciences - https://www.firebirdbio.com/ Foundation for Applied Molecular Evolution - http://www.ffame.org/ Remember to like, subscribe, and hit the notification bell to stay updated on our latest content! #syntheticbiology #nucleicacids #dna Disclaimer: Genome TDCC does not endorse or recommend any commercial products or services. Inclusion of a speaker's views or opinions on our channel does not constitute endorsement by Genome TDCC, The Jackson Laboratory (JAX), National Human Genome Research Institute (NHGRI), or the U.S. Government. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not constitute or imply its endorsement, recommendation, or favoring to the exclusion of other available products, processes, or services.