Скачать с ютуб Hyperpolarized Xe NMR in Molecular Cavities Study and MR Imaging | Prof. Leif Schröder | Session 83 в хорошем качестве

Hyperpolarized Xe NMR in Molecular Cavities Study and MR Imaging | Prof. Leif Schröder | Session 83

During the 83rd session of the Global NMR Discussion Meetings held on March 26th, 2024 via Zoom, Prof. Leif Schröder from the German Cancer Research Center gave a talk on the topic "Hyperpolarized Xenon NMR for Exploring Molecular Host Cavities and Advancing MR Imaging". The recording serves as a tutorial. Prof. Schröder's research : https://www.dkfz.de/en/translationale... Abstract: The large chemical shift range of Xe-129 NMR makes this nucleus a valuable probe in spectroscopy and biomedical imaging. Hyperpolarized Xe can be used also as dissolved noble gas to provide 10’000-fold improved sensitivity over extended periods of time. In combination with saturation transfer techniques, reversibly bound hyperpolarized xenon gives insights into exchange kinetics of various host-guest complexes. This talk will give an overview of studies investigating the affinity of dissolved Xe for various hosts like biogenic hollow protein structures with attoliter volumes or synthetic hosts for trapping individual Xe atoms. Both strategies find applications in the spectroscopic investigation of exchange kinetics of host-guest systems and in the design of ultra-sensitive magnetic resonance imaging agents. Content of this video : 00:00 - 21:42 Introduction : NMR with Caged Xe 21:43 - 37:27 Applications with Synthetic Hosts 37:28 - 46:49 Biogenic Hosts 46:50 - 56:40 Q&A Current organizers: Adrian Draney (Creighton Uni., Chemistry) Amrit Venkatesh (Florida State University, National High Magnetic Field Laboratory) Asif Equbal (New York Uni., Abu Dhabi) Blake Wilson (Robert Tycko Lab, NIH) Michael Hope (Warwick Uni., Chemistry) Mouzhe Xie (Maurer Lab, Uni. Chicago) Nino Wili (Niels Chr Nielsen Lab, Aarhus Uni.) Nesreen Elathram (Debelouchina Lab, UCSD) Charlotte Bocquelet (HMRLab, CRMN Lyon)