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The Science of Metabolic Health: Mitochondria, Zone 2, Diet, Fat Storage | The Proof Podcast EP

Boost metabolic health and prevent disease with expert insights from an all-star lineup of scientists in Episode #329. Learn key strategies for improving metabolic health, including metabolic flexibility, muscle health, and the critical roles of diet and exercise in preventing type 2 diabetes and fatty liver disease. 👇 Visit The Proof website for the full show notes and supporting studies. 👇 https://theproof.com/podcast/ In this episode, you’ll hear from a distinguished panel of specialists including applied exercise physiologist Inigo San Millan, PhD; skeletal muscle expert Don Layman, PhD; type 2 diabetes authority Roy Taylor, PhD; dietitian and researcher Andrea Glenn, PhD, RD; nutrition scientist Alan Flanagan, PhD; nutrition scientist and endocrinologist Christos Mantzoros MD, DSc, PhD; and physician and researcher Richard Johnson, MD. Specifically, we discuss: Intro (00:00) What is Metabolic Health (01:35) Metabolic Health, Mitochondria, Defining 'Metabolise', Metabolic Flexibility (07:02) The Importance of Skeletal Muscle for Metabolic Health (20:03) Exercise for metabolic health - Zone 2 (28:36) Twin Cycle Hypothesis (56:45) Understanding the Personal Fat Threshold (01:08:15) Summary of the DiRECT Trial: Examining the Twin Cycle Hypothesis with Roy Taylor (01:17:08) Are DASH, Nordic, Mediterranean, and Portfolio diets good for preventing and managing diabetes? (01:36:46) Understanding Non-Alcoholic Fatty Liver Disease and Its Development (01:42:39) The Science of Hepatic Fat Oxidation (01:49:37) Consequences and Effects of Fatty Liver Disease (01:55:14) Linking Non-Alcoholic Fatty Liver Disease with Type 2 Diabetes (02:00:42) Combination of Fructose and Saturated fat on Metabolic Health (02:13:21) Type of fat and its effect on Metabolic Health (02:17:35) What cause Metabolic Health: fat or fructose (02:24:01) New Fat Storage Mechanisms - Personal Fat Threshold (02:27:50) Modern Techniques for Accurate Body Fat Measurement (02:31:52) Health metabolic biomarkers (02:36:51) Ectopic fat (02:38:19) Fat storage and metabolic health (02:39:10) Evolutionary Insights into Human Fat Storage (02:42:02) Fatty Liver Disease (02:45:46) Outro (2:57:46) Connect with featured guests: - Inigo San Millan, PhD: https://theproof.com/tag/inigo-san-mi... - Don Layman, PhD: https://theproof.com/tag/don-layman/ - Roy Taylor, PhD: https://theproof.com/tag/roy-taylor/ - Andrea Glenn, PhD, RD: https://theproof.com/tag/andrea-glenn/ - Alan Flanagan, PhD: https://theproof.com/tag/alan-flanagan/ - Richard Johnson, MD: https://theproof.com/tag/richard-john... - Christos Mantzoros MD, DSc, PhD: https://theproof.com/tag/christos-man... The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. Enjoy, friends. Simon This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Head to https://38tera.com https://38tera.com/ and use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com http://eimele.com/ and use code SIMON at checkout for 10% off your first order. LMNT Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon http://drinklmnt.com/simon Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends http://theproof.com/friends You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com http://theproof.com/ and host of The Proof with Simon Hill https://theproof.com/podcast/ Author of The Proof is in the Plants https://theproof.com/book/ Watch the episodes on YouTube https://www.youtube.com/c/TheProofWit... or listen on Apple https://podcasts.apple.com/au/podcast... / Spotify https://open.spotify.com/show/7bAIJCV... Connect with me on Instagram   / theproof   , Twitter   / theproof  , and Facebook   / theproofwithsimonhill   Nourish your gut with my Plant-Based Ferments Guide https://theproof.com/ferments/ Download my complimentary Two-Week Meal Plan https://plantproof.com/mealplan and high protein Plant Performance recipe book https://theproof.com/performance/