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What Is Life Extension? | LifeXtenShow

There are a lot of misconceptions about life extension; in this episode, Nicola explains what LE actually is. Liked the show? Let us know at   / lifespanio   or our Discord server at   / discord   Facebook:   / lifespanio   LinkedIn:   / lifespanio   Instagram:   / lifespan.io   Website: https://www.leafscience.org/ Stock contents: Shutterstock.com, Videoblocks.com Intro jingle courtesy of Kevin MacLeod -------------------------- Sources: Compression of morbidity: Fries, J. F. (1980). Aging, Natural Death, and the Compression of Morbidity. New England Journal of Medicine, 303(3), 130–135. The Hallmarks of Aging López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217. https://www.cell.com/abstract/S0092-8... Senolytics: Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., ... & Khazaie, K. (2016). Naturally occurring p16 Ink4a-positive cells shorten healthy lifespan. Nature, 530(7589), 184. Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., ... & McGuckian, C. (2018). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine, 36, 18-28. Walaszczyk, A., Dookun, E., Redgrave, R., Tual‐Chalot, S., Victorelli, S., Spyridopoulos, I., ... & Richardson, G. D. (2019). Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction. Aging cell, e12945. Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., Van De Sluis, B., … & van Deursen, J. M. (2011). Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature, 479(7372), 232-236. Tchkonia, T., Zhu, Y., Van Deursen, J., Campisi, J., & Kirkland, J. L. (2013). Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. The Journal of clinical investigation, 123(3), 966-972. Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., … & O’Hara, S. P. (2015). The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging cell, 14(4), 644-658. Velarde, M. C., & Demaria, M. (2016). Targeting Senescent Cells: Possible Implications for Delaying Skin Aging: A Mini-Review. Gerontology. Childs, B. G., Baker, D. J., Wijshake, T., Conover, C. A., Campisi, J., & van Deursen, J. M. (2016). Senescent intimal foam cells are deleterious at all stages of atherosclerosis. Science, 354(6311), 472-477. Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., ... & Onken, J. L. (2018). Senolytics improve physical function and increase lifespan in old age. Nature medicine, 24(8), 1246. Unity Biotechnology's website: http://unitybiotechnology.com 9000-year lifespan: https://gizmodo.com/if-you-could-only... -------------------------- #Aging #LifeExtension #Rejuvenation #LifeXtenShow #Lifespan #Healthspan #CompressionOfMorbidity ►Subscribe for more: http://www.youtube.com/user/LifespanI... ►This video is presented by LEAF. Please support our work by becoming a Lifespan Hero: http://lifespan.io/hero