Скачать с ютуб The Hallmarks of Aging: Stem Cell Exhaustion | LifeXtenShow в хорошем качестве

The Hallmarks of Aging: Stem Cell Exhaustion | LifeXtenShow

Your cells don’t last forever; for one reason or another, they pretty much all die and need to be replaced. This is the job of stem cells, the "cellular students" of your body that specialize into specific types of cells and repopulate your cellular workforce. But what happens when your body runs out of students? Liked the show? Let us know on Twitter at   / lifespanio   or our Discord server at   / discord   Facebook:   / lifespanio   LinkedIn:   / lifespanio   Instagram:   / lifespan.io   Website: https://www.leafscience.org/ Stock contents: Shutterstock, Videoblocks Music: Intro jingle courtesy of Kevin MacLeod - Incompetech.com -------------------------- Sources: The Hallmarks of Aging López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217. (https://www.ncbi.nlm.nih.gov/pmc/arti...) Telomerase expression in stem cells Yui, J., Chiu, C. P., & Lansdorp, P. M. (1998). Telomerase activity in candidate stem cells from fetal liver and adult bone marrow. Blood, 91(9), 3255-3262. (https://www.ncbi.nlm.nih.gov/pubmed/9...) Link between pathologies of aging and stem cell exhaustion Pietras EM, Warr MR, Passegué E. Cell cycle regulation in hematopoietic stem cells. J Cell Biol. 2011;195(5):709–720. doi:10.1083/jcb.201102131 (https://www.ncbi.nlm.nih.gov/pmc/arti...) Stem cell exhaustion and immune function decline Shaw, A. C., Joshi, S., Greenwood, H., Panda, A., & Lord, J. M. (2010). Aging of the innate immune system. Current opinion in immunology, 22(4), 507-513. (https://www.ncbi.nlm.nih.gov/pmc/arti...) Link between pathologies of aging and stem cell exhaustion Ahmed, A. S. I., Sheng, M. H., Wasnik, S., Baylink, D. J., & Lau, K. H. W. (2017). Effect of aging on stem cells. World journal of experimental medicine, 7(1), 1. (https://www.ncbi.nlm.nih.gov/pubmed/2...) Link between genomic instability and stem cell exhaustion Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007). Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature, 447(7145), 725. (https://www.ncbi.nlm.nih.gov/pubmed/1...) About stem cell niches Ferraro, F., Celso, C. L., & Scadden, D. (2010). Adult Stem Cels and Their Niches. The Cell Biology of Stem Cells, 155–168. (https://www.ncbi.nlm.nih.gov/pubmed/2...) Stem cell injections against aging frailty Tompkins, B. A., DiFede, D. L., Khan, A., Landin, A. M., Schulman, I. H., Pujol, M. V., ... & Mushtaq, M. (2017). Allogeneic mesenchymal stem cells ameliorate aging frailty: a phase II randomized, double-blind, placebo-controlled clinical trial. The Journals of Gerontology: Series A, 72(11), 1513-1522. (https://www.ncbi.nlm.nih.gov/pmc/arti...) About stem cell transplants Abdelkrim, H., Juan, D.-B., Jane, W., Mohamed, A., & Bernat, S. (2009). The immune boundaries for stem cell based therapies: problems and prospective solutions. Journal of Cellular and Molecular Medicine, 13(8a), 1464–1475. (https://www.ncbi.nlm.nih.gov/pmc/arti...) About stem cell transplants Fields, M., Cai, H., Gong, J., & Del Priore, L. (2016). Potential of Induced Pluripotent Stem Cells (iPSCs) for Treating Age-Related Macular Degeneration (AMD). Cells, 5(4), 44. (https://www.ncbi.nlm.nih.gov/pubmed/2...) Gutierrez-Aranda, I., Ramos-Mejia, V., Bueno, C., Munoz-Lopez, M., Real, P. J., Mácia, A., … Menendez, P. (2010). Human Induced Pluripotent Stem Cells Develop Teratoma More Efficiently and Faster Than Human Embryonic Stem Cells Regardless the Site of Injection. STEM CELLS, 28(9), 1568–1570. (https://www.ncbi.nlm.nih.gov/pmc/arti...) -------------------------- #StemCells #CellTherapy #Aging #MolecularBiology #Biology #LifeExtension ►Subscribe for more: http://www.youtube.com/user/LifespanI... ►This video is presented by LEAF. Please support our work by becoming a Lifespan Hero: http://lifespan.io/hero