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Ask Doctors - Get Video Answers in HINDI Subscribe to - / @doctorscirclehindi for HINDI videos There is a lot of confusion which is arising now about pain and painless vaccines. Doubts about which is superior. All you need to know about this is pain and painless vaccines is in DPT and DTwP. that is where the pertussis component will vary. The DTwP has whole cell pertussis vaccine whereas DTAP is Acellular Pertussis Vaccine. That’s the main difference between a pain and a painless vaccine. The vaccinations when initiated were all DTwP vaccines which were used for 80 to 90 years in the market. Since most of these DTwP vaccines were causing undesirable side effects like fever, swelling and some neurological symptoms, Japanese were the first to being abut an acellular vaccine that causes undesirable side effects. The acellular pertussis vaccine of different manufacturers are available on the market for the last 30 years and have been used in most developing nations. The whole confusion has arised after they have encountered an outbreak of pertussis in California. So it has to be understood that such similar outbreaks of pertussis have occurred even in developing nations like Pakistan and India. What is important in these outbreaks is that pertussis does not give 100% protection. The efficacy of pertussis is just 85% with either of these vaccinations.