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N-Acetylcysteine for ADHD?

Here is a free link to my Article on N-acetylcysteine: https://medium.com/wise-well/a-supple... Follow   / dockruse   on Medium for hundreds of full length articles on this subject and more! Access to other Medium articles requires paid membership. Main Chapters: 00:00 Intro 00:20 Take home message 01:48 What is N-Acetylcysteine? (NAC) 04:56 Medical Uses of NAC 11:59 NAC and ADHD 16:43 Potential Side Effects of NAC 17:40 Conclusion 19:25 Outro N-acetylcysteine (NAC to friends) is widely available as a supplement and is FDA approved to treat poisoning from acetaminophen (Tylenol.) It boosts the level of a tri-peptide, glutathione, inside of brain cells, and increases the amount of glutamate available in the synaptic space. NAC has generated intense interest in the mental health field, because in addition to increasing glutamate, and (probably indirectly) dopamine and serotonin, it also has potent anti-inflammatory and anti-oxidative damage properties. Multiple studies support that it can be helpful with OCD, depression, and schizophrenia. A single study suggests that it may also benefit those with ADHD. High doses of oral forms of NAC can cause nausea and other gastrointestinal effects, but it is generally well tolerated at dosages that might help with ADHD. References: Attention Deficit and Hyperactivity Scores are Elevated and Respond to N-Acetylcysteine Treatment in Patientss with Systemic Lupus Erythematosus (2013) https://onlinelibrary.wiley.com/doi/e... Findings from a pilot open-label trial of N-acetylcysteine for the treatment of pediatric mania and hypomania (2022) https://www.ncbi.nlm.nih.gov/pmc/arti... N-Acetyl Cysteine in the Treatment of Obsessive Compulsive and Related Disorders: A Systematic Review https://www.ncbi.nlm.nih.gov/pmc/arti... Glutamate/glutamine and neuronal integrity in adults with ADHD: a proton MRS study https://www.ncbi.nlm.nih.gov/pmc/arti... Full Chapter List: 00:00 Intro 00:20 Take home message 01:48 What is N-Acetylcysteine? (NAC) 03:32 Glutathione 04:56 Medical Uses of NAC 05:06 NAC for Tylenol Detoxification (Acetaminophen / Paracetamol) 06:31 Acetaminophen / Paracetamol Overdose 07:52 Clinical Experience of Tylenol Poisoning 09:51 NAC as a Mucolytic 10:25 NAC as a Supplement 11:59 NAC and ADHD 12:09 Study on NAC and ADHD 14:41 Study Results and Analysis 15:46 Other Research on NAC and Mental Health 16:43 Potential Side Effects of NAC 17:40 Conclusion 19:25 Outro ------------------------- Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions. Subscribe if you're curious about how neuro-atypical brains can optimize their functioning in our shared, and somewhat strange, world. Dr. Kruse has posted talks in both the "live" and the "video" sections of this channel. Thumbnails on ADHD topics have a pink background, and those on more general mental health topics have a purple background. A small collection of ADHD-Trump videos have an orange background. You're welcome to email him with topics you want discussed or people you think he should interview. [email protected]