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Immunogenicity causing Antidrug Antibodies: How, Why, Which cells, What and When? 3 года назад


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Immunogenicity causing Antidrug Antibodies: How, Why, Which cells, What and When?

#immuneresponse #immune #Tcell #Bcell #antibodies #CD4 #CD8 #immunology #allergy #education #medicine #immunogenicity #publichealth #vaccine This is an educational video that provides a high level explanation of what is immunogenicity Images created based on the following references: 1) Dis Model Mech. 2012 July; 5(4): 423–433.; 2) Microbes and Infection Volume 11, Issue 5, April 2009, Pages 625–630; 3) Cellular Immunology Volume 275, Issues 1–2, Jan–Feb 2012, Pages 12–18; 4) Blood September 1, 2006 vol. 108 no. 5 1571-1579 ; 5) Inflamm Bowel Dis, 7: 43–50 (2001) ; 6) Nature Cell Biology 7, 381 - 386 (2005) ; 7) Immunology, 93: 257–263 (2001) ; 8) Cytokine & Growth Factor Reviews Volume 15, Issue 1, February 2004, Pages 49–60; 9) J Clin Invest. 2005;115(2):282–290.; 10) Immunological Reviews, 102: 5–28; 1998; 11) Immunity Volume 16, Issue 4, April 2002, Pages 559–569; 12) The Journal of Immunology December 1, 1992 vol. 149 no. 11 3495-3502 13) Nature Reviews Immunology 8, 193-204 (March 2008); 14) Abbas, Lichtman and Pillai. Basic Immunology, 9th edition, 2017; 15) Gorovitz et al. Clin Exp Immunol. 2018 Jun;192(3):348-365. doi: 10.1111/cei.13112 In addition, Saleem Basha Shaik, PhD brought to my attention a paper that explains that both Th1 and Th2 can induce B cell maturity or differentiation. Below is the published article showed it is both Th1 and Th2. A L Rothermel 1, K M Gilbert, W O Weigle. Cell Immunol. 1991 Jun;135(1):1-15

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