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Before you start taking Tacrolimus, make sure to read the Patient Information Leaflet from your pharmacist. Take this medication exactly as directed by your doctor, usually every 12 hours. It can be taken with or without food, but it's important to choose one way and stick to it to ensure consistent absorption. If you are taking the capsules, swallow them whole and do not open or crush them. If you are using the granules, be sure to follow the manufacturer's Instructions for Use and use non-plastic cups, spoons, or oral syringes. Do not sprinkle the granules on food and do not prepare the mixture ahead of time. The dosage of Tacrolimus is based on your weight, medical condition, lab tests, and response to treatment. It's important to take this medication regularly at the same times each day to keep the amount of medicine in your body at a constant level and get the most benefit from it. Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. And if you are pregnant or may become pregnant, do not handle this medication or breathe the dust from the capsules. Remember to consult your doctor if your condition worsens. a5b7