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The Serotonin Hypothesis of Psychosis

Learn the essentials of psychopharmacology from Dr. Stephen Stahl! This clip from Stahl’s Essential Psychopharmacology, Video Edition covers the serotonin hypothesis of psychosis. Learn more: https://nei.global/epvideos Although serotonin receptors and synapses are ubiquitous throughout the brain, the serotonin hyperfunction hypothesis of psychosis suggests that psychosis may be caused by an imbalance in excitatory 5HT2A receptor stimulation of those glutamate pyramidal neurons discussed above that directly innervate VTA/mesostriatal integrated hub dopamine neurons and visual cortex neurons. The hallucinogens LSD, mescaline, and psilocybin, which are all powerful 5HT2A agonists, have long been known to induce psychosis, dissociative experiences, and especially visual hallucinations by overstimulating prefrontal and visual cortex 5HT2A receptors. These symptoms can be blocked by 5HT2A antagonists, demonstrating that hallucinogens cause psychosis by 5HT2A stimulation. About: In Stahl’s Essential Psychopharmacology: Video Edition, the newly published fifth edition of the landmark textbook comes to life as Dr. Stahl himself presents every chapter with fully animated illustrations. Learn more: https://nei.global/epvideos Stay updated with email alerts: https://nei.global/updates Copyright © Neuroscience Education Institute. All rights reserved. Interested in more Psychopharmacology? Check out the NEI Master Psychopharmacology Program: https://nei.global/mpp Follow us on Facebook: https://nei.global/facebook Follow us on LinkedIn: https://nei.global/linkedin Follow us on Twitter: https://nei.global/twitter Listen to the NEI Podcast! Spotify: https://nei.global/podcastspotify Apple Podcast: https://nei.global/podcastapple Podcast Website: https://nei.global/podcast