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Opening lecture for the symposium "Looking in the Right Direction: Carl Woese and the New Biology," to mark the official renaming of the Carl R. Woese Institute for Genomic Biology at the University of Illinois at Urbana-Champaign. Lecture given by Penny Chisholm, Lee and Geraldine Martin Professor of Environmental Studies, Massachusetts Institute of Technology. Phytoplankton form the base of ocean food webs and are responsible for half the photosynthesis on Earth. As such, they play a central role in our planet’s metabolism. Less than a micron in diameter, Prochlorococcus is the smallest and most abundant member of the phytoplankton—single-handedly manufacturing billions of tons of living biomass each year. Dr. Chisholm and her lab have focused their research on advancing the understanding of this globally significant microbe since its discovery three decades ago. This tiny cell has begun to change the way we think about living systems. Dr. Chisholm describes this journey, and shares some of the many insights Prochlorococcus has given us over the years.