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Stimulants and Cardiovascular Risks

Follow   / dockruse   on Medium for hundreds of full length articles on this subject and more! Free link to article on Stimulants and Cardiovascular Risks: https://medium.com/wise-well/your-med... Access to other Medium articles requires paid membership. Main Chapters: 00:00 Intro 00:14 Take home message 01:41 Why Focus on Cardiovascular Issues? 08:26 Studies on Stimulants and Cardiovascular Issues 16:24 How to Prevent Potential Cardiovascular Issues 22:10 Conclusion 23:39 Questions Medications, particularly stimulants, remain the best documented and most potent treatments for ADHD. But we know that many of our medications, including forms of amphetamine (Adderall, Vyvanse), methylphenidate (Ritalin, Concerta), atomoxetine (Strattera), and bupropion (Wellbutrin) increase blood pressure and heart rate slightly in the first weeks and months of treatment. A 2022 meta-analysis of almost four million patients failed to find negative cardiac health impacts from ADHD medications. But a more recent, longer term study (2-7 years), comparing those with ADHD and cardiovascular disease to those with ADHD but no cardiovascular disease, found that ADHD medications were statistically associated with hypertension and arterial disease. Longer use, and higher doses posed the biggest risks. But the medications were not linked to arrhythmias, heart attacks, strokes, heart failure or other serious events with blood clots. Numerous headlines claimed that the new evidence showed how dangerous ADHD medications are. Although the research has important public health implications, most patients should be reassured by the low risk to any particular individual. Only 4% of the participants had a newly diagnosed cardiovascular condition arise during the years of the study. References: Attention-Deficit/Hyperactivity Disorder Medications and Long-Term Risk of Cardiovascular Diseases (2023) https://jamanetwork.com/journals/jama... Risk of Cardiovascular Diseases Associated With Medications Used in Attention-Deficit/Hyperactivity Disorder A Systematic Review and Meta-analysis (2022) https://jamanetwork.com/journals/jama... Long-term methylphenidate exposure and 24-hours blood pressure and left ventricular mass in adolescents and young adults with attention deficit hyperactivity disorder https://www.sciencedirect.com/science... Autonomic and endocrine control of cardiovascular function (2015) https://www.ncbi.nlm.nih.gov/pmc/arti... Full Chapter list: 00:00 Intro 00:14 Take home message 01:41 Why Focus on Cardiovascular Issues? 03:05 Stimulants and Heart Rate / Arrhythmia 04:47 Stimulants and Arteries / Blood Pressure 07:01 Hypertension 08:26 Studies on Stimulants and Cardiovascular Issues 08:43 Study Showing No Impact of Stimulants 10:19 Study Showing Some Impact of Stimulants 12:58 Study Results 14:36 Study Analysis 16:24 How to Prevent Potential Cardiovascular Issues 16:36 Electrocardiogram (EKG/ECG) 17:36 Blood Pressure Monitoring 19:16 Differences in Medication Types / Formulations / Dosages 21:29 Other ADHD Risk Factors for Cardiovascular Issues 22:10 Conclusion 23:39 Questions 23:53 Blood Pressure Increase with Stimulants and Alternatives 24:43 Hypertensive Medication with Stimulants 25:47 Stress and Depression 26:38 Stimulants Lowering Blood Pressure 27:17 Dealing with Doctors Blaming ADHD Medication 28:56 Stimulants and Stress / Cortisol Levels 30:21 Outro Streamed live January 31, 2024 ------------------------- Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions. Subscribe if you're curious about how neuro-atypical brains can optimize their functioning in our shared, and somewhat strange, world. Dr. Kruse has posted talks in both the "live" and the "video" sections of this channel. Thumbnails on ADHD topics have a pink background, and those on more general mental health topics have a purple background. A small collection of ADHD-Trump videos have an orange background. You're welcome to email him with topics you want discussed or people you think he should interview. [email protected]