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Ancient DNA (aDNA) data generated by the Proyecto de Investigación de Poblaciones Antiguas en el Norte y Occidente de México (PIPANOM) are providing new insight on the people who lived in central, western, and northern Mexico hundreds and thousands of years ago. Data from over 300 individuals spread across Mexico, including from archaeological sites such as Tzintzuntzan, Cueva de los Muertos Chicos, and Paquimé, have shed light onto long-standing questions about migration and interaction of different archaeological cultures in key eras of Mexico’s past. In this October 19, 2024, "Third Thursday Food for Thought" presentation for Old Pueblo Archaeological Center, archaeologist/geneticist Dr. Jakob Sedig discusses how the PIPANOM dataset has revealed previously unknown information about the individuals who lived at these sites, and how combining the PIPANOM data with previously published aDNA data from across the Americas allows researchers to understand better the movement and interaction of different groups across cultural boundaries. Dr. Sedig also reviews how the PIPANOM research has brought together archaeologists, geneticists, researchers, analysts, and students from different backgrounds and countries. If you have appreciated videos posted by Old Pueblo Archaeology Center, please consider making a donation to our organization online at https://www.oldpueblo.org/about-us/do... or, for longer-term support, see how you can become a member of Old Pueblo’s "Archaeology Opportunities" membership support organization by visiting https://www.oldpueblo.org/about-us/me....