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The first episode features PDB-ID 8QQG: BRAF in complex with exarafenib Great minds do think alike. Or perhaps they don’t? What goes through the mind of a drug hunter when facing a new challenge? In “What The Drug?!” we will dive into the thought processes, strategies, and problem-solving techniques of medicinal and computational chemists. The concept: No script. At the beginning of the session, a project is disclosed and its aims are defined. What follows is a freestyle design session where compound design decisions are commented on, providing insights into the creative and analytical processes that drive drug discovery. During the whole event, the viewers are openly invited to comment and share their input. Anything can happen: Tasks such as “Design a nanomolar binder for target X” or “Suggest five novel scaffolds in compound Y” may arise. With the defined goal in mind, we will use BioSolveIT applications to creatively explore solutions from various angles, innovate compound design, and push the boundaries of what’s possible in drug discovery. Science coupled with ingenuity.