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Benadryl also know as diphenhydramine represents a first generation antihistamine that may improve allergy symptoms and counteracts certain types of itching and urticaria / hives. While still popular for treating the common cold, the idea it provides benefit in this regard was disproved by the military more than a half century ago. Benadryl or diphenhydramine ranks among the most frequent sleep aids either by itself or as Nytol or Tylenol PM. Unfortunately it interrupts the normal sleep architecture and leads to next morning grogginess especially among the elderly. Actually use of this medication by senior citizens may create more problems than it solves. Common side effects of Benadryl / diphenhyramine include constipation, urinary hesitancy or inability to void, dry eyes, dry mouth and mental confusion. The second generation antihistamines – Allegra, Claritin, Zyrtec also available as generics – provide comparable relief of allergy symptoms without many of the adverse reactions. For nasal allergies, inhaled corticosteroid sprays generally offer greater relief and more rapid onset of action with fewer side effects.