Скачать с ютуб Extrinsic Pathway of Apoptosis | FAS Ligand Mediated в хорошем качестве

Extrinsic Pathway of Apoptosis | FAS Ligand Mediated

In this video the second pathway for extrinsic apoptosis have been discussed. This pathway is mediated via FAS Ligand and FAS Receptor. The fas receptor (First apoptosis signal) – (also known as Apo-1 or CD95) is a transmembrane protein of the TNF family which binds the Fas ligand (FasL). The interaction between Fas and FasL results in the formation of the death-inducing signaling complex (DISC), which contains the FADD, caspase-8 and caspase-10. In some types of cells (type I), processed caspase-8 directly activates other members of the caspase family, and triggers the execution of apoptosis of the cell. In other types of cells (type II), the Fas-DISC starts a feedback loop that spirals into increasing release of proapoptotic factors from mitochondria and the amplified activation of caspase-8.