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PDE inhibitors for the treatment of erectile dysfunction. WHY??

In this video, the discussion on why PDE (phosphodiesterase) inhibitors are used in erectile dysfunction. For penile erection, there is a release of NO (nitric oxide) which is a vasodilator. NO activates guanylyl cyclase to increase cGMP which gets degraded by PDE-5. PDE-5 inhibitor preserves cGMP. Drugs like sildenafil (viagra) and tadalafil act via this mechanism. Channel details: Welcome to my physiology learning channel. I am Dr. Ramkumar S MBBS, MD, DNB physiology. Explain why series will help you to understand concepts in physiology, solve MCQs, answer in Viva, and theory exams. Happy Learning. #physiology #explainwhyseries #PDEinhibitor #erectiledysfunction #sildenafil Suggested book links For MBBS students Ganong’s Review of Medical Physiology - https://amzn.to/3GoArCq Guyton and Hall Textbook of Medical Physiology - https://amzn.to/3LTgwNp For Postgraduates in Physiology Berne and Levy Physiology - https://amzn.to/38QDMhi Boron Physiology - https://amzn.to/38owktL Gadgets to make video Iphone - https://amzn.to/3GsL07Q Screen recording - https://amzn.to/39ZTE1t Writing - https://amzn.to/3wQOg9A Lighting - https://amzn.to/3lMUqRM Softbox - https://amzn.to/39WW3d5 Mic - https://amzn.to/3wS8kIR Tripod - https://amzn.to/3wNHj9n Mobile holder - https://amzn.to/38QQaxX