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Our Vice Mexico team went to the Sonora desert in search of the Bufo Alvarius, an endemic toad species that contains a very high dosage of 5-MEO-DMT in it´s body. 5-MEO-DMT is said to be the most potent hallucinogenic in the world. Our guide through this trip was Octavio Rettig, a doctor who has studied this toad for more than eight year and has brought the medicine - as he calls the substance - all over the world. We went to Punta Chueca, Sonora, where we hanged out with the indigenous community who has been taking 5-MEO-DMT from the toad since pre-hispanic times. We met Grandpa Pancho - one of the elders of the town - and travelled with him to the sacred island of Isla Tiburón. There we had a small ceremony where we tried the substance for the very first time. Watch more Episodes of Mexicalia: http://bit.ly/Mexicalia Click here to subscribe to VICE: http://bit.ly/Subscribe-to-VICE Check out our full video catalog: http://bit.ly/VICE-Videos Videos, daily editorial and more: http://vice.com More videos from the VICE network: https://www.fb.com/vicevideos Like VICE on Facebook: http://fb.com/vice Follow VICE on Twitter: / vice Read our Tumblr: / vicemag Follow us on Instagram: / vice