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Origins of the RNA-Protein World – Lost in Translation?, John Sutherland, Cambridge

John Sutherland Medical Research Council Laboratory of Molecular Biology, Cambridge "Origins of the RNA-Protein World – Lost in Translation?" The RNA-protein double act at the heart of biology raises several intriguing origins questions that can be addressed by prebiotic chemistry. Beyond the obvious ‘which came first?’, one can also wonder about the extent to which chemistry shaped the process of translation according to the genetic code. In this lecture I will describe some mixed hydrogen cyanide-hydrogen sulfide chemistry that produces nucleotides and amino acids. Some degree of control is necessary for this ‘cyanosulfidic’ chemistry to proceed most efficiently and ways in which environmental factors could exercise this control will be suggested. Synergies in the assembly of nucleotide and amino acid building blocks into higher order structures will then be discussed as will experimental hints of a previously proposed second genetic code. Finally, it will be shown how the strength of codon-anticodon binding likely influenced the partial initial assignment of the primary genetic code. The Origins of Life Speaker Series explores the conditions and circumstances that led to the diversity of life on Earth. The interdisciplinary series will connect the formation of planets, the evolution of early Earth, and the complex chemistry and delivery of the fundamental organic molecules that serve as the building blocks of early life, and how they can establish complex, self-replicating systems of cells and genetic material. Learn more: https://physicalsciences.uchicago.edu... ➡ Subscribe:    / @physicalsciencesdivisionun8258   About the University of Chicago Physical Sciences Division The Physical Sciences Division (PSD) at the University of Chicago has a rich history of advancing and defining new fields of discovery in the physical and mathematical sciences, and this tradition of innovation continues today. Our inquiry and impact spans from the edge of the observable universe to human-computer interaction, from biophysical materials science to the geologic record of seawater composition, from gravitational waves to geometric flows, and beyond. The division includes the academic departments of Astronomy & Astrophysics, Chemistry, Computer Science, Geophysical Sciences, Mathematics, Physics, and Statistics. In addition, PSD is home to a number of interdisciplinary research institutes and centers, including the Enrico Fermi Institute, the James Franck Institute, and the Kavli Center for Cosmological Physics. #UChicagoPSD on the Web: Home: https://physicalsciences.uchicago.edu Facebook:   / uchicagopsd   Twitter:   / uchicagopsd   Instagram:  / uchicagopsd   University of Chicago Physical Sciences Division on YouTube:    / @physicalsciencesdivisionun8258