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logP (Partition Coefficient) and Lipid Solubility of Drugs || Junaid Asghar PhD

Why 1-Octanol? You could, in theory, use any non-polar solvent that is immiscible with water for the determination of logP. However, the properties of 1-octanol are thought to resemble those of lipid bilayer membranes rather well (i.e., the distribution of chemicals/drugs into 1-octanol simulates their ability to passively diffuse across membranes in living systems). Until someone discovers a better solvent system, water/1-octanol will remain as the standard. Under the European Union’s chemicals legislation, logP has to be determined for every substance manufactured or imported in 1 ton or more per year. logP of a compound can be determined by high-performance liquid chromatography (HPLC). Because compounds differ widely in their solubilities and analytical properties, various analytical methods have been used for this purpose, such as acid/base titration, ultraviolet (UV) photometry, gas chromatography analysis, and other chromatographic techniques. Crucially, the acid/base profile of a compound has a direct effect on the lipophilicity (logP) of a substance in the body as governed by the ionization constants (pKa values) of the key "Functional Groups" in different environments (pH). Lecture on PKa of a drug:    • Drug Absorption | Concept of pKa and ...   #LogP #LipidSolubilityOfDrugs #PartitionCoefficient