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Many people are frustrated by their persistent toenail fungus. People with toenail fungus which is also called onycomycosis have thickened, fragile or cracked toenails. Their toenails have whitish to yellow-brown discoloration and may be deformed. The most effective and inexpensive treatment for confirmed toenail fungus is an oral medication called terbinafine. The medication is taken once a day for 12 weeks. It costs $27 at Walmart with a goodRX coupon. The clinical cure rate is 38 to 76 %. Terbinafine tablets are contraindicated in patients with Chronic or active liver disease. The most frequent side effects of terbinafine are headache, gastrointestinal disturbance such as diarrhea and/or dyspepsia), rash and elevated liver enzymes Terbinafine can interact with other medications such as tricyclic antidepressants, selective serotonin reuptake inhibitors, tamoxifen, beta-blockers etc. Other Treatment Options include: Oral Medications: Fluconazole (Diflucan) Itraconazole (Sporanox) Topical Solutions: Ciclopirox 8% Efinaconazole (Jublia) 10% Tavaborole (Kerydin) 5% Procedures: Toenail removal Laser treatment