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The validation study and real-world data demonstrated Cap-Score(TM) was consistent with home collection (HC) versus immediate processing at the clinic. Reductions in concentration were anticipated with HC, as a minimum of 10x10^6 cells was originally required with processing at clinics, whereas no minimum was set for HC. Home collection would allow clinics with limited andrology staff to focus on other responsibilities. It may help to encourage men who are concerned with producing at an office or delivering samples to a clinic, to pursue fertility workups. It may also increase the availability of fertility evaluations to individuals that live far from clinics and decrease costs related to travel and time off work.