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Medicinal #leechtherapy (MLT) or hirudotherapy is a kind of complementary and integrative treatment method applied with blood-sucking leeches. One or more leeches are attached to the skin of problematic area and the purpose is to gain potential utilities of leech saliva that is secreted while the leeches are feeding. MLT has been used for centuries and the term leech was provided from the word “laece” (physician). MLT has become an important part of much scientific research. Leeches live in fresh water and are segmented, hermaphrodite, carnivorous worms. They are sensitive to vibrations on the water, touch, light, heat, sound, and various chemicals. They are multisegmented, including “brain parts”, and each segment has different organs such as ganglions and testicles. Two sucker parts work for creeping and adherence; the anterior one has three jaws including many teeth. They generally bite warm parts of the host and suck its blood with rhythmic contractions.Feeding usually takes almost 40 minutes and a leech digests 10–15 mL of blood per feeding. Digestion is achieved by many enzymes and mutual microorganisms such as Aeromonas hydrophila and Pseudomonas hirudinia. MLT was previously tested and is widely used after plastic, reconstructive, and microsurgical applications, in cardiovascular diseases, deep vein thrombosis, postphlebitic syndrome, complications of diabetes mellitus, tinnitus, acute and chronic otitis, and in reducing the pain of osteoarthritis.There are more than 600 leech species, but Hirudo medicinalis, Hirudo troctina, Hirudo nipponia, Hirudo quinquestriata, Poecilobdella granulosa, Hirudinaria javanica, Hirudinaria manillensis, Haementeria officinalis,