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Dr. Lauren Madigan describes VEXAS syndrome, an acquired autoinflammatory multisystemic disease that preferentially affects adult males over the age of 40. In addition, Dr. Madigan discusses differential diagnosis, common symptom presentation, and treatment resistance associated with this disorder. ExchangeCME.com is an online community of more than 55,000 active healthcare professionals who have access to a variety of enduring educational activities and other disease state–focused resources. The Website’s core mission is to support patient-centered care via education that is tailored to the needs of various clinician audiences. By consolidating evidence-based resources and hosting only accredited educational programs without any promotional content or advertising, ExchangeCME.com serves as an independent, trusted, and balanced source of free CME/CE for physicians, nurses, pharmacists, and other healthcare providers. Follow us on social! twitter: / exchangecme facebook: / exchangecme linkedin: / exchangecme #SM #systemicmastocytosis #VEXAS #autoinflammatory