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Sarah Tishkoff: Human Population Genetics and Origins

CARTA celebrates its 10th anniversary with a whirlwind tour of anthropogeny, the study of the origin of humans, by addressing these questions across multiple disciplines: What do we know for certain? What do we think we know? What do we need to know? How do we proceed? Recorded on 3/23/2019. [8/2019] [Show ID: 34702] Donate to UCTV to support informative & inspiring programming: https://www.uctv.tv/donate More from: CARTA 10th Anniversary: Revisiting the Agenda (https://www.uctv.tv/carta-10th) Explore More Science & Technology on UCTV (https://www.uctv.tv/science) Science and technology continue to change our lives. University of California scientists are tackling the important questions like climate change, evolution, oceanography, neuroscience and the potential of stem cells. UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California -- teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world. (https://www.uctv.tv) 0:00 Introduction 1:52 Key Challenges in Human Evolutionary Genomics Research 2:43 What we need to know. When and where did modern humans originate in Africa? 3:12 What we need to know: How many migrations where there out of Africa and what were the source populations? 3:43 What we need to know: Was there admixture with archaic populations in Africa? 5:30 Measuring Phenotypic Diversity 6:32 High Coverage Whole Genome Sequencing in Africa 8:15 What we need to know What is the molecular mechanism of human adaptation? 8:58 Skin Color is an Adaptive Trait 10:17 Genome Wide Association Study 10:25 SLC24A5 13:14 Gene Geneology of MFSD12 using genome sequence data from Simons Genome Diversity Project 14:00 A Selective Sweep in Eurasians 14:35 OCA2/HERC2 15:21 Age of Derived Alleles 15:38 Evolution of human skin pigmentation 16:35 How do we proceed?