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Salicylic acid and its binding proteins at the crossroads of plant and human health

Dr Daniel Klessig, Boyce Thompson Institute, Cornell University presented a QAAFI Science Seminar titled "Salicylic acid and its binding proteins at the crossroads of plant and human health". During the past several years, we have identified over two dozen plant SA-binding proteins (SABPs), primarily through biochemical methods including three high-throughput screens (http://bioinfo.bti.cornell.edu/SA2010/). SA binding alters the biochemical and/or biological activities of these proteins. This work has been extended to humans, since the most widely used medicine aspirin (acetyl SA) is rapidly converted to SA after ingestion and SA has most of the same pharmacological activities of aspirin. Two novel targets of SA/aspirin have been identified across the animal and plant kingdoms. Together the two human SABPs are associated with most of the major human diseases, including heart attack, arthritis, cancers, and Alzheimer’s and Parkinson’s diseases. Read more: http://bit.ly/2CKAniB