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SCSAP MSS -May 20th, 2024 - Michael Elowitz Ph.D., Caltech 4 месяца назад


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SCSAP MSS -May 20th, 2024 - Michael Elowitz Ph.D., Caltech

Michael Elowitz Ph.D. Howard Hughes Medical Institute Investigator and Professor of Biology and Biological Engineering, and Applied Physics, Caltech  TITLE: Many-to-many protein networks: computation modules for multicellular systems   ABSTRACT: In multicellular organisms, many biological pathways exhibit a curious structure, involving sets of protein variants that bind or interact with one another in a many-to-many fashion. What functions do these seemingly complicated architectures provide? And can similar architectures be useful in synthetic biology? Here, I will discuss recent work in our lab that shows how many-to-many circuits can function as versatile computational devices, explore the roles these computations play in natural biological contexts, and show how many-to-many architectures can be used to design synthetic multicellular behaviors

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