Скачать с ютуб Depression in Restless Legs Syndrome (RLS) from Dopamine Agonist Discontinuation в хорошем качестве

Depression in Restless Legs Syndrome (RLS) from Dopamine Agonist Discontinuation

Dopamine agonist medications including pramipexole (Mirapex®), ropinirole (Requip®), and rotigotine (Neupro®) had been first-line treatment for restless legs syndrome (RLS), but after more than two decades of use in this condition, it is now apparent that they should no longer be used to treat RLS with rare exception, due to risk of inevitable augmentation, impulse control disorders, chemical dependence, and overall disruption of the dopaminergic system in the brain. However, the negative effects of these drugs on mood often go unnoticed, particularly after successful tapering off and elimination of the drug as a treatment in individuals with augmentation. Watch this video explaining what augmentation is:    • What is Augmentation in Restless Legs...   Andy Berkowski, MD of ReLACS Health reports on the ways in which these medications-and the withdrawal from them-lead to dopamine dysfunction in the brain. The impairment to the brain's natural dopamine system can affect sensations, movements, decision-making, and mood. Here, loss of appropriate dopaminergic function can lead to anhedonia, which is derived from the Greek, meaning loss of enjoyment in normally pleasurable activities. This causes a person to be resistant to the common activities that typically produced emotional enjoyment. Despite the improvement to RLS and sleep quality after recovery from dopamine agonist withdrawal, for months thereafter, some patients lose the enjoyment of life and this can lead to other symptoms of depression or even thoughts of suicide. Unfortunately, the easiest solution is to restart dopamine agonists, which would stop the withdrawal and natural recovery process and give the artificial dopamine stimulation back, which is what the withdrawing brain craves. However, this will just set the individual back to where they were during augmentation and chemical dependence on these medications. There are no well-studied solutions currently. From a lifestyle standpoint, setting goals and motivating oneself to engage in social interaction and normally pleasurable activities can be a start. Therapy from a licensed mental health profession can be essential and free of drug side effects, more importantly. These individuals can help with medical doctors to monitor for increasing levels of depression, including self-harm or suicidal thoughts. Medications can be used to combat the effects of depression, specifically bupropion (Wellbutrin®), which is the only RLS-neutral antidepressant. Other classic SSRI or SNRI medications may be needed, even at the risk of worsening RLS slightly, which can be overcome with other RLS treatments for the sake of improvement to mood. In all, this is yet another reason why providers should stop prescribing dopamine agonists for RLS. If you are someone you know expresses thoughts of self-harm or suicide, this is a medical emergency, please call the Mental Health Crisis Hotline at 988 anywhere in the U.S. or go to the nearest psychiatric emergency department. You may read more about why dopamine agonists are bad for RLS in A ReLACSing blog: https://www.relacshealth.com/blog/v3h... To watch how these medications lead to impulse control disorders:    • Impulse Control Disorders in Restless...   For an overview of how to taper off dopamine agonists:    • How to Taper off Dopamine Agonists fo...   For those that are unsure of what RLS is:    • Does Restless Legs Syndrome Exist?   Despite affecting about 5% of the U.S. population, RLS is highly ignored in the medical field. Read an analysis of why this may be: https://www.relacshealth.com/blog/a-r... In Memoriam Robert H. May his soul rest in peace.