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Severe Combined Immunodeficiency | ABP Board Review 10 месяцев назад


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Severe Combined Immunodeficiency | ABP Board Review

This is a snippet from Dr. Sonal R. Patel’s Allergy & Immunology lecture in MedStudy’s 2023-2024 Pediatrics Video Board Review. https://medstudy.com/products/pediatr... Severe Combined Immunodeficiency • IL-2Rγ defect • IL-7Rα defect • RAG deficiency • CD3 receptor defect • JAKF3 defect • ZAP-70 defect • ADA deficiency • PNP deficiency • Reticular dysgenesis • Omenn syndrome • Bare lymphocyte syndrome • Presents 1st few months of life • Clinical presentation – Eczematous-like skin lesions – Chronic lung infections – Chronic diarrhea – Failure to thrive – Absent thymus shadow – Lymphopenia – Septicemia • Medical emergency Combined B- and T-Cell Defects • B-Cell Defect – Recurrent sinopulmonary infections • Bacteria: Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus • Virus: enterovirus • Protozoa: Giardia • T-Cell Defect – Intracellular organisms and opportunistic infections • Bacteria: Salmonella, syphilis • Mycobacteria: MTB, MAC, MAI • Virus: CMV, HSV, VZV, EBV • Fungi: Candida, Aspergillus, cocci, Cryptococcus, histoplasmosis • Protozoa: PJP, toxoplasmosis, isosporiasis, microsporidiosis Continue your review: https://medstudy.com/products/pediatr... Subscribe to our YouTube channel:    / @medstudycom   Follow us on: Instagram:   / medstudystrong   Facebook:   / medstudy   Twitter:   / medstudy   TikTok:   / medstudystrong   #Pediatricians #Pediatrician #Pediatrics #Peds #ABP #AOBP #boardexam #boardprep #meded #medicaleducation #allergy #immunology #immunologist #allergist

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