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Grignard Reagent - Detailed Concepts 🔥 || Mechanism || All Possible Reactions || IITian Explained 5 лет назад


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Grignard Reagent - Detailed Concepts 🔥 || Mechanism || All Possible Reactions || IITian Explained

The Grignard reagent is a highly reactive organomagnesium compound formed by reacting a haloalkane with magnesium in an ether solvent. The carbon atom of a Grignard reagent has a partial negative charge. The Grignard reagent is a versatile material that can be used to form new carbon–carbon bonds. It acts as a nucleophile and attacks the carbonyl carbon atom to give an alkoxide which forms a salt with (MgBr)+. Hydrolysis of the magnesium bromide salt gives the alcohol. To determine how to combine two molecules to give an alcohol in a Grignard synthesis, examine the substituents bonded to the carbon bearing the hydroxyl group. One component of the new compound can come from the Grignard reagent. The other component must have been present in a carbonyl compound. 1. Primary alcohols are made from a Grignard reagent and formaldehyde. 2. Secondary alcohols can be made by reacting a Grignard reagent with an aldehyde. 3. Tertiary alcohols can be made by reacting a Grignard reagent with a ketone. The use of the Grignard reagent is precluded if there is an acidic hydrogen in the substrate selected to react with the Grignard reagent. This acidic hydrogen destroys the Grignard reagent before it adds to the carbonyl group. If the substrate has a hydroxyl group, it can be protected by forming a trimethylsilyl ether. ——————————————————————————————————————————————————— Our Online Telegram Group for All JEE and Medical Aspirants: https://t.me/joinchat/NYB5GhRN-cwBF7A... ——————————————————————————————————————————————————— Follow MKA Sir to Get all Special Free Live Classes on Unacademy https://unacademy.com/@kcf521 ——————————————————————————————————————————————————— After huge demand of Students,Finally team IITian Explains has launched the complete course for JEE2020. Use Code "IITIANEXPLAINS"to get 10% off Subscription Link:https://unacademy.com/plus/goal/TMUVD Course Details Link:https://unacademy.com/plus/course/ran... Features: 1.Lecture Pattern Just like KOTA 2.Complete Syllabus covered before January attempt of JEE-Main 2020. 3. Tips and Tricks 4.Daily Practice Problems(DPPs) 5.Discussion of DPPs 6.Special Question Bank for revision 7. Complete revision will start after January JEE Main 8. Weekly Quiz and Rank Booster Tests especially designed by Core IITian Explains Team. ——————————————————————————————————————————————————— Mesomeric Effect in Organic Chemistry    • Mesomeric Effect in Organic Chemistry...   General organic chemistry    • Carbocations and Carbanions | General...   Which is more stable tertiary carbocation with 9 alpha H or benzyl carbocation?    • Which is more stable tertiary carboca...   Sodium Borohydride in Organic chemistry    • Sodium Borohydride in Organic Chemist...   LiAlH4 in One Shot    • LiAlH4 in One Shot | Concept Booster ...   DIBAL_H in organic chemistry    • DIBAL-H in Organic Chemistry || Expla...   We hope this would be very benificial for you guys. Thanks Keep Sharing….Keep Supporting!!!! MKA Sir

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