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The Two Faces of Mirtazapine: Linking Its Dose-Dependent Mechanisms to Clinical Practice

Welcome to our deep dive into Mirtazapine, a distinctive medication classified as a Noradrenergic and Specific Serotonergic Antagonist (NaSSA). In this video, Dr Sanil Rege, Consultant Psychiatrist, takes you on a journey exploring the fascinating dual effects of Mirtazapine at varying doses, shedding light on its unique action on receptor profiles and how this translates to its efficacy and tolerability in clinical practice. Mirtazapine stands out for its ability to provide relief from anxiety, depression, and even nausea in certain medical conditions, thanks to its action on a variety of receptors, including the 5HT2A, 5HT2C, and 5HT3, as well as its histaminergic and noradrenergic activities. At lower doses (15-30 mg), Mirtazapine acts primarily through serotonin-specific antagonism, offering benefits like anti-anxiety effects, improved sleep quality, and no sexual dysfunction, distinguishing it from other antidepressants. However, its antihistamine properties act as a limiting factor due to weight gain. As we increase the dose (45-60 mg), we unlock Mirtazapine’s noradrenergic effects, crucial for treating severe forms of depression through the potentiation of noradrenaline and dopamine. Moreover, we will compare Mirtazapine with Mianserin, highlighting the reasons behind Mirtazapine's preference in clinical settings despite their similarities, including Mianserin's association with agranulocytosis. This video is your comprehensive guide to understanding Mirtazapine's pharmacodynamics, its clinical applications, and how its receptor-specific actions contribute to its side effects and benefits at different dosages. Whether you're a healthcare professional, a student, or someone interested in the science behind psychiatric medication, join us to unravel the complexities of Mirtazapine and how it's used to combat various psychiatric and physical symptoms. If you find value in our content, please like this video, share your experiences in the comments, and subscribe for more insightful updates. For more resources, visit the link in the description. #MirtazapineMechanisms #NaSSAExplained #DualDoseEffects #MirtazapineVsMianserin #DepressionTreatment #AnxietyRelief #Pharmacodynamics #MentalHealthMedication #SerotoninAntagonism #NoradrenergicBoost Key Moments: 0:00 Mirtazapine's mechanism of action and dosage effects. 1:45 Serotonin receptors and their effects on depression and other symptoms. 3:18 Mirtazapine's benefits and side effects. 4:51 Mirtazapine's effects on sedation, weight gain, and noradrenaline. 6:41 Mirtazapine's effects on serotonin and dopamine. Relevant Resources: Psychopharmacology Masterclass👉https://www.academy.psychscene.com/co... 🎓RESOURCES BY PSYCH SCENE: 🌐The Academy by Psych Scene: PSYCHIATRY EDUCATION REDEFINED https://academy.psychscene.com/ Revolutionary psychiatry learning. 🌐Psych Scene Hub: PSYCHIATRY TEXTBOOK OF THE FUTURE https://psychscenehub.com/ The Hub is devoted to making you a better mental health professional. Our team of academic and clinical experts bring you powerful summaries, videos and interviews in psychiatry and neurosciences. 🌐Psych Interview Online: REAL WORLD SKILLS FOR REAL WORLD SUCCESS https://www.psychinterview.com/ The Psych Interview online courses offer high-quality training to help you improve your psychiatric interview skills through self-study. 🌐Psych Scene Online: THE ONLINE COURSES TO HELP YOU SUCCEED https://ranzcpexams.psychscene.com/ Learn at your own pace with the RANZCP Written Exam prep online courses. 🌐Psych Scene: THE PSYCHIATRY TRAINING EXPERTS https://psychscene.com/ Psych Scene offers specialised training and professional development for Psychiatry Trainees, Psychiatrists, General Practitioners and Mental Health Practitioners. -- 📱SOCIALS Subscribe for weekly videos on Psychiatry and Neuroscience: Facebook:   / psychscenehub   Instagram :   / psychiatry.excellence   – 👋 LET’S CONNECT! Follow Sanil Rege on LinkedIn:   / sanilrege