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The purpose of this presentation is to examine genomic sequencing and its’ effects on identifying and understanding molecular-level interactions between nutrients and their subsequent bio-actives on health and recovery. To provide an enhanced scientific and rational means to optimize nutrition with respect to an individual’s genotype as the evolution of nutrition could have an effect on gene expression. As our nutrition evolves, our SNPs (single nucleotide polymorphisms) that occurs at a specific position in the genome, can lead to appreciable differences in enzyme or protein function. Clinically noted, microbiome efficiency as well as autophagy, detoxification, methylation, mitochondria, histamine, neurotransmitter, and immune/inflammatory response increased by genetic predisposition and triggering events leads to a propagation of disorder: inability to resolve the metabolic deficiency/inflammatory state. To overcome genetic weakness, we must take into careful consideration the evolution of our nutrition.