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Lymphoma: Overview of Classification

This Harvard Medical School Continuing Education video examines these key questions: how are lymphomas classified, and what are the key features of lymphomas? Dr. Connor Johnson, MD, an oncologist at Massachusetts General Hospital, compares the traditional system for classifying lymphomas, which begins with separating them into Hodgkins and non-Hodgkins buckets, to a more easily digestible framework of lymphoma subtype archetypes that groups indolent, aggressive and very aggressive lymphomas together. The presentation and histology of several important lymphoma subtypes are reviewed. 00:00 | Introduction 00:34 | Traditional lymphoma classification 01:42 | Lymphoma subtype archetypes 03:02 | Follicular lymphoma 03:45 | Diffuse large B-cell lymphoma (DLBCL) 04:48 | Burkitt lymphoma 05:42 | Hodgkin lymphoma 06:35 | Summary This video was peer reviewed by Dr. Jonathan Salik, TMD, MHPEd, Instructor of Medicine, Massachusetts General Hospital; and Dr. Sugantha Sundar, MD, Assistant Professor of Anesthesia, Beth Israel Deaconess Medical Center, to validate the quality and accuracy of the content. It was edited by affiliate physicians of Harvard Medical School, Arielle J Medford, MD, Senior Medical Oncology Fellow, Dana-Farber Cancer Institute and Anna Handorf, MD, Research Fellow in Pediatrics, Massachusetts General Hospital. References: Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues. 4th ed. International Agency for Research on Cancer; 2017. Casulo C. How I manage patients with follicular lymphoma. Br J Haematol. 2019;186(4):513-523. doi:10.1111/bjh.16011 Sehn LH, Salles G. Diffuse Large B-Cell Lymphoma. N Engl J Med. 2021;384(9):842-858. doi:10.1056/NEJMra2027612 Lap CJ, Nassereddine S, Dunleavy K. Novel Biological Insights and New Developments in Management of Burkitt Lymphoma and High-Grade B-Cell Lymphoma. Curr Treat Options Oncol. 2021;22(7):60. Published 2021 Jun 7. doi:10.1007/s11864-021-00857-w Crombie JL, LaCasce AS. Current considerations in AYA Hodgkin lymphoma. Br J Haematol. 2019;184(1):72-81. doi:10.1111/bjh.15640 Notice: At this time, the content in this video is not accredited.