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This webinar introduces how biomarkers are used in therapeutic development and clinical practice, discusses the importance of “fit for purpose” validation studies, and provides a brief overview of NINDS funding landscape for biomarker discovery and validation research. We were joined by two guest panelists, Dr. Fred Korley, who discussed his research experiences validating biomarkers for traumatic brain injury, and the need for biomarkers in clinical trials, and Dr. Diaz-Ortiz, who talked about her experience in biomarker discovery work for Parkinson’s Disease and how they’re moving from discovery to translation. After the panel discussion there was a Q&A with the audience. Speakers for this webinar included: Carol Taylor-Burds, PhD: Program Officer, Division of Translational Research Christine Swanson-Fischer, PhD: Program Officer, Division of Neuroscience Tjerignimin Adissa Silue, PhD: Health Program Specialist, Division of Translational Research Fred Korley, MD, PhD: Associate Professor, Emergency Medicine, University of Michigan Maria Diaz-Ortiz, PhD: MD/PhD student, University of Pennsylvania For more information on this webinar and other webinars in the series, check out: https://bit.ly/OPENStage-Jan23