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Since its discovery in 1977, the hepatitis delta virus (HDV), a complicated passenger virus of hepatitis B, has been baffling scientists and evading successful control for over 40 years. Inducing the most severe form of viral hepatitis known to humans, HDV has the ability to promote rapid liver disease, often within only several years after infection. What makes this virus so difficult to understand? Why have we been unable to find successful treatments to save patient lives? What clinical trials show the most promise? Join Dr. Jean-Michel Pawlotsky, Chief of Biology at the French National Reference Center for Viral Hepatitis B, C and delta as he describes delta's moleculary virology and epidemiology, diagnostics, unique challenges in treatment, and the promising research being done to combat this aggressive RNA virus. Join Dr. Jean-Michel Pawlotsky, Chief of Biology at the French National Reference Center for Viral Hepatitis B, C and delta as he describes the virus, unique challenges, and the promising research being done to combat this aggressive RNA virus.