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Optimizing Oral Testosterone Undecanoate (Kyzatrex) TRT: All You Need to Know

Dr. Andrew Sun, a top urologist in Dallas, discusses the new form of oral testosterone, Kyzatrex, and its potential benefits: it is safe on the liver, easy to take, requires no injections, provides a more natural testosterone level variation, and may help to preserve fertility. The FDA approved Kyzatrex, a fresh form of oral testosterone, in 2019. This new formulation does not go through the liver and is thus not liver-toxic. Oral testosterone undecanoate (T.U.) is taken twice daily, with doses ranging from 100 to 200 mg per capsule. Patients typically take two capsules twice a day, amounting to 400, 600, or 800 mg daily. Oral T.U. offers advantages over other testosterone forms, including better safety, easier titration, and a lower risk of side effects like blood pressure increases. Its unique absorption mechanism involves a phytosterol ester that helps the testosterone absorb through the lymphatic system, bypassing the liver. Studies show that oral T.U. effectively raises testosterone levels, with average serum testosterone levels reaching therapeutic ranges within 3 to 5 hours of dosing. Oral T.U. also has an effect on sex hormone-binding globulin (SHBG) levels, which can increase the proportion of free, biologically active testosterone. This may be beneficial for patients with high SHBG levels who may have symptoms of low testosterone despite normal total levels. Ongoing studies are investigating the long-term effects on sperm production and overall fertility. Dr. Sun discusses the effectiveness of Kyzatrex, an oral testosterone replacement therapy (TRT), and its potential benefits. He suggests that low, medium, and high-fat diets result in similar testosterone absorption, and recommends taking it with substantial food for the best results. Most patients achieve therapeutic testosterone levels, with a peak around 3 to 5 hours post-dose, and a twice-daily dosing regimen can be customized to align with a patient's daily routine and energy needs. Oral T.U. shows a lower incidence of adverse effects compared to injectable forms, particularly concerning high blood pressure and polycythemia. The drug's absorption method minimizes the risk of liver toxicity. Kyzatrex is suitable for a variety of patients, including those who have experienced side effects from injectable testosterone, younger men who want to preserve fertility, and first-time testosterone users who may be needle-averse or looking for a less invasive option. Dr. Sun emphasizes the importance of staying informed about the latest developments and data in the evolving landscape of TRT research. For more information: https://www.kyzatrex.com/ Dr Andrew Sun's Clinic: https://www.upnt.com/physicians/md-an... Related video: https://www.excelmale.com/threads/int...