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Sleep and Beyond: How Basic Research is Leading a Revolution in Circadian Medicine

The Rockefeller University December 6, 2023 Speaker: Sofia Axelrod, Ph.D. Research Associate Laboratory of Genetics The Rockefeller University Host: Jessica Hopfield, Ph.D. ’91 Healthcare Strategist and Investor President, J Hopfield Consulting Sleep, or lack thereof, has become a major health concern. As we understand more and more about the link between poor sleep and impaired learning and memory, weakened resistance to infection, and chronic diseases like diabetes to depression, scientists are attempting to address how to deal with sleep deprivation in an increasingly demanding world. If longer, sounder sleep is essential, what does this mean for jet-lagged travelers, sleep-deprived teens, overwhelmed shift workers, or those suffering from sleep disorders? What are strategies we can use and how can we better structure our lives around good sleep health? Dr. Sofia Axelrod, a research associate in the Laboratory of Genetics headed by Nobel laureate Dr. Michael Young, discusses her study of the basic function and regulation of circadian rhythms, sleep, as well as the mechanisms of aging. This intersection of biology and human behavior is connecting Nobel Prize-winning discoveries to everyday lived experiences, unlocking the secrets to a good night’s sleep, and revealing potential treatments for clinical disorders. This program was hosted by Dr. Jessica Hopfield ’91, a scientist and business leader in the medical and healthcare fields. She is a former partner at McKinsey & Company in their Global Pharmaceutical and Medical Device practice. Dr. Hopfield is a graduate of Rockefeller University having trained in the Laboratory of Molecular and Cellular Neuroscience headed by the late Dr. Paul Greengard where she was also a postdoc.