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Anterior Myocardial Infarction ECG Features of Anterior STEMI ST segment elevation with subsequent Q wave formation in precordial leads (V1-6) +/- high lateral leads. These changes are often preceded by hyperacute T waves Reciprocal ST depression in inferior leads (mainly III and aVF) Clinical Relevance of Anterior Myocardial Infarction Anterior STEMI usually results from occlusion of the left anterior descending artery (LAD). Anterior myocardial infarction carries the poorest prognosis of all infarct locations, due to the larger area of myocardium infarct size. A study comparing outcomes from anterior and inferior infarctions (STEMI + NSTEMI) found that compared with inferior MI, patients with anterior MI had higher incidences of: In-hospital mortality (11.9 vs 2.8%) Total mortality (27 vs 11%) Heart failure (41 vs 15%) Significant ventricular ectopic activity (70 vs 59%) Lower ejection fraction on admission (38 vs 55%) In addition to anterior STEMI, other high-risk presentations of anterior ischaemia include left main coronary artery (LMCA) stenosis, Wellens syndrome and De Winter T waves. Clinical Pearls: ECG Patterns to Recognize 1. Wraparound LAD STEMI Anterior-inferior STEMI due to LAD occlusion ST elevation in precordial and inferior leads 2. Left Main Coronary Artery Stenosis Widespread ST depression ST elevation in aVR ≥ V1 3. Wellens Syndrome (Pre-Infarction Warning Sign) Deep precordial T wave inversions or biphasic T waves in V2-3 Indicates critical proximal LAD stenosis 4. De Winter T Waves (STEMI Equivalent) Upsloping ST depression Symmetrically peaked T waves in precordial leads Indicates acute LAD occlusion Key Takeaways Recognize these ECG patterns to quickly identify high-risk coronary artery disease Prompt intervention can prevent myocardial infarction