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#114

Original release date: 6/8/20 In this episode, Eileen White, Chief Scientific Officer at the Rutgers Cancer Institute, describes the fundamental role of autophagy in the maintenance of health and prevention of neurodegeneration, cancer, and other diseases. She also goes into detail about the paradoxical finding that autophagy may benefit an existing cancer cell and help it to survive—a discovery leading to new possibilities in cancer therapy. We also discuss fasting (and molecules that induce autophagy) and the critical need to decode the proper fasting “dose” in order to improve human health. We discuss: 00:00:00 - Intro 00:03:40 - Eileen’s discovery that a specific oncogene blocks apoptosis 00:10:00 - Defining apoptosis and its role in cancer prevention 00:17:20 - How cancer cells use the autophagy pathway to survive 00:29:15 - Stressors that induce autophagy 00:32:45 - The importance of autophagy in the brain and liver 00:40:00 - The mechanisms that can trigger autophagy to support longevity 00:42:30 - Evidence for cancer treatment by blocking autophagy 00:46:45 - Types of cancer that are most autophagy-dependent 00:52:40 - The autophagy paradox 00:59:15 - Finding a molecular signal for autophagy 01:13:00 - Current knowledge gaps around fasting as a tool for longevity 01:22:15 - Rapamycin, metformin, and other molecules that may induce autophagy 01:32:50 - How to study fasting and exercise as longevity tools 01:36:45 - The Nobel Prize for autophagic research 01:38:25 - Eileen’s future areas of research 01:49:25 - A fasting strategy for Alzheimer’s disease prevention 01:51:30 - Future study of metabolism and autophagy Show notes page: https://peterattiamd.com/eileenwhite/ ----- About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 30 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://peterattiamd.com Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle