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Selectively Silencing Nociceptor Sensory Neurons│Prof. Clifford J. Woolf

Summary: Local anesthetics decrease the excitability of all neurons by blocking voltage-gated sodium channels non-selectively. We have developed a technology to silence only those sensory neurons – the nociceptors – that trigger pain, itch, and cough. I will tell you why and how we devised the strategy, the way we showed that it works, and will also discuss its implications for treating multiple human disorders. Speaker Bio: Clifford J. Woolf, MB, BCh, PhD, was born and educated in South Africa, became a Neurobiology Professor at University College London, then the Richard J. Kitz Professor of Anesthesiology Research, Massachusetts General Hospital/Harvard Medical School. Presently, he is the F. M. Kirby Neurobiology Center Director, Boston Children’s Hospital, and a Neurology/Neurobiology Professor at Harvard Medical School. Dr. Woolf’s many honors and prizes include membership in the American Academy of Arts and Sciences, a Doctoris Honoris Causa (University of Lausanne, Switzerland), a Gill Distinguished Scientist Award, and the Reeve-Irvine Medal. He works on adaptive and maladaptive plasticity of the nervous system. Moderator: Mosab Ali Awadelkareem, Al-Neelain University, Sudan. Society of Neuroscientists of Africa – SONA: https://sonafrica.org/   / sonaorg     / society-of-neuroscientists-of-africa-sona-...      / @societyofneuroscientistsof385   TReND in Africa: https://trendinafrica.org/ https://www.flickr.com/photos/trendin... https://twitter.com/trendinafrica?lan...   / trendinafrica   Worldwide Neuro: https://www.worldwideneuro.com/   / worldwideneuro