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The question is missed period sand headache in PCOS. Missed period in reproductive age group, always we should think of pregnancy, whether she is PCOS case or not, PCOS, we think there is no ovulation is not possible to conceive. But that is wrong. Occasionally in PCOS people can ovulate and pregnancy is possible. Headache may happen in pregnancy is the first 3 months. However this is not the symptom of pregnancy. In association of PCOS, headache should not be neglected because PCOS can be associated with a condition called as hyperprolactinemia. That is the prolactin hormone, which is secreted by a small gland in the brain may get increased during PCOS. So this condition is called as hyperprolactinemia. So in PCOS people they should be evaluated by the treating physician before you come to a conclusion that it may be pregnancy.