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Hedgehog Signaling Pathway

This video unravels the intricate dance of the Hedgehog Signaling Pathway, a master controller in animal development! Ever wondered how a single pathway orchestrates the growth of organs and tissues? Here, we'll witness the key players - Hedgehog, Patched, Smoothened, and Ci - working in concert. Without the Hedgehog signal, it's all quiet: Ci, a gene activator, gets constantly broken down. Proteins like Fused and Costal2, along with kinases, tag Ci for destruction, keeping Hedgehog target genes off. Patched, a receptor, holds Smoothened, another protein, inactive. But when Hedgehog arrives, the music starts! Hedgehog binds to Patched, freeing Smoothened. Phosphorylated Smoothened interacts with the Fused-Costal2 complex, releasing Ci. Unbound Ci travels to the nucleus, activating Hedgehog target genes. These genes control critical processes like: Cell destiny - choosing the right path for each cell! Tissue organization - building structures in the right place. Growth - ensuring proper development. Join us as we explore the fascinating world of Hedgehog signaling! #HedgehogPathway #DevelopmentalBiology #CellCommunication #GeneActivation Leave a comment below with your questions about this amazing pathway!