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The beneficial effect of ketamine on chronic pain is mediated by reductions in depression, according to a new study. One of my first clinical rotations as a medical student was the pediatric emergency room. On my second day there, a 6-year old was brought in with an ulnar fracture – he had fallen from a jungle gym. I stood aside, like a frightened medical student does, and watched as an incredibly talented ER nurse put an IV into the screaming child and administered… something. In seconds, the kid was calm. The screaming stopped. Not asleep, his eyes were open, but he wasn’t exactly… there. The orthopedic team quickly set the fracture and put on a cast. That was it. Within about 20 minutes, he was fine. Up and around, talking to his parents. Getting an ice cream. That substance the nurse administered? Ketamine. I had never seen anything like it. To be honest, I still haven’t. It is just a fundamentally different anesthetic. Ketamine for the acute pain of a broken bone is relatively safe and highly effective. But what about chronic pain? Like the pain of fibromyalgia, or peripheral neuropathy? The data suggests it may help – but the reason it may help could surprise you. Click here to subscribe: https://www.youtube.com/c/methodsmanm... Get more medical news analysis at https://www.methodsman.com or https://www.medscape.com