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In recognition of Dry Eye Awareness Month 2021, the Alliance for Eye and Vision Research (AEVR), joined by the Tear Film & Ocular Surface Society (TFOS), host their sixth annual Dry Eye Congressional Briefing. The briefing consists of an interview-style discussion led by AEVR Executive Director James Jorkasky, who is a Dry Eye Disease (DED) patient. Key leaders from TFOS’ next Global Workshop entitled “A Lifestyle Epidemic: Ocular Surface Disease,” will also address the latest in lifestyle and environmental factors that result in Dry Eye. This latest initiative follows TFOS’ Dry Eye Workshop II (TFOS DEWS II™) Report, released in July 2017 and published in The Ocular Surface journal. That re-examination of TFOS’ initial 2007 Report updated the definition, classification, and diagnosis of DED; critically evaluated the epidemiology, pathophysiology, mechanism and impact of the disease; addressed its management and therapy, and developed recommendations for design of clinical trials to assess therapies.