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Preparation of Benzilic Acid from Benzil | DU MSc Organic Lab

Experiment File PDF Link : https://drive.google.com/file/d/1vaZk... Preparation of Benzilic Acid from Benzil: The preparation of benzilic acid from benzil involves a well-known organic reaction called the benzilic acid rearrangement. This reaction is a base-catalyzed rearrangement of a 1,2-diketone (benzil) to an α-hydroxy acid (benzilic acid). Procedure Overview: Dissolving Benzil: Benzil (C₁₄H₁₀O₂), a yellow crystalline compound, is dissolved in ethanol or an alcohol solvent. Addition of Base: A strong base like potassium hydroxide (KOH) or sodium hydroxide (NaOH) is then added to the benzil solution. This initiates the rearrangement process by generating a carbanion at one of the carbonyl groups in benzil. Rearrangement: The carbanion undergoes a 1,2-shift, with a migration of the phenyl group, forming an intermediate that is then protonated to form benzilic acid. This step converts one carbonyl group to a carboxylate and the other to an alcohol group. Acid Work-up: The reaction mixture is then acidified using dilute hydrochloric acid (HCl) to convert the carboxylate into benzilic acid (C₁₄H₁₂O₃). Reaction Mechanism: The base deprotonates the α-hydrogen of one of the carbonyl groups of benzil. A phenyl group migrates to the adjacent carbonyl carbon, resulting in the formation of a new carbanion. Protonation of this carbanion leads to the formation of benzilic acid. Final Product: The white crystalline solid of benzilic acid is obtained after recrystallization. Benzilic acid is widely used in organic synthesis, including the preparation of pharmaceuticals and other chemical intermediates. ‪@GeneralDiscussionwithArvind‬ #BenzilicAcid #BenzilRearrangement #OrganicChemistry #BenzilicAcidPreparation #ChemistryExperiments #ChemicalReaction #BenzilToBenzilicAcid #BenzilicAcidSynthesis #ChemistryTutorial #OrganicSynthesis #RearrangementReaction #NucleophilicAttack #BenzilicRearrangement #ChemistryLab #ChemistryStudent #ReactionMechanism #AcidBaseChemistry #ChemicalTransformation #ChemistryEducation #Benzil #HydroxideAttack #ChemicalRearrangement #OrganicLab #BenzilicAcidMechanism #ChemistryLearning #ChemicalReactionMechanism #ChemistryLecture #OrganicReactions #ChemLab #SynthesisReaction #LabWork #ChemistryTips #OrganicChemistryReactions #RearrangementMechanism #Acidification #ChemistryCommunity #ChemistryClass #OrganicChem #BenzilicSynthesis #ChemistryKnowledge #LabExperiments #ChemistryDemonstration #ChemicalSynthesis #BenzilicAcidFormation #ReactionSteps #ChemistryHelp #LabProcedure #ReactionSequence #SynthesisOfBenzilicAcid #OrganicChemLab #ChemistryForStudents #ChemistryFacts #BenzilMechanism #Recrystallization #ReactionPathway #ChemistryEducationTools #StudyChemistry #OrganicReactionsLab #OrganicReactionSteps #RearrangementInChemistry #HydroxideIonAttack #BenzilReaction #LearnChemistry #ChemistryResources #ChemicalReactionsExplained #ReactionChemistry #ChemistryLearningHub #ChemicalProcesses #LabChemistry #OrganicChemistryExperiments #ChemistryPractical #AcidBaseReactions #RearrangementProcess #PotassiumHydroxideReaction #BenzilicAcidYield #ChemicalMechanisms #ChemistryNotes #SynthesisMechanism #ChemicalFormation #RearrangementReactionsInChemistry #OrganicChemistryTips #ChemistryFundamentals #BenzilicAcidStudy #ChemistryStudentsOfInstagram #BenzilicMechanismSteps #LabChemist #AdvancedChemistry #ReactionMechanismsExplained #ChemicalScience #ChemistryInstructor #TeachingChemistry #StudyOrganicChemistry #LabSynthesis #ChemistryProcesses #ChemicalRearrangementSteps #BenzilicRearrangementMechanism #OrganicRearrangement #ChemistryIsFun #PracticalChemistry #ChemistryTutorials #ChemistryLabWork