Скачать с ютуб Active learning cell free protein production optimization в хорошем качестве

Active learning cell free protein production optimization

Speaker: Dr. Olivier Borkowski, INRAE, France Abstract: Lysate-based cell-free systems have become a major platform to study gene expression, but batch-to- batch variation makes protein production difficult to predict. During this webinar, you will learn about an active learning approach to explore a combinatorial space of approximately 4,000,000 cell-free compositions, maximizing protein production and identifying critical parameters involved in cell-free productivity. Also, discover a one-step-method to achieve high quality predictions for protein production using minimal experimental effort regardless of the lysate quality. Join molecular physiologist and microbial bioengineer, Olivier Borkowski from Institut Pasteur and Inria, who is working on model bacteria and yeast. His scientific interest, from his PhD to current work, focuses on the relationship between cell physiology and gene expression. During his PhD, he worked on B. subtilis to understand the impact of growth rate on protein production using a systems-oriented approach. Then, during his postdoc, he focused on the impact on protein production on the growth rate. He has developed a method to predict the cost of heterologous protein production using cell-free systems (in vitro expression) and models of the translation process. In parallel, he used synthetic biology approaches to build: Genetic circuits sensing the changes in cell physiology in different growth phases to control protein production in E. coli using genetic logic gates Autonomous "feedback control" circuits to sense and reduce the weight of resource competition between the host and synthetic circuits Learn more: https://becls.co/3A599hW MAPSS Approval Code: 20.11.269.AUTO Disclaimer: These products are not intended or validated for use in the diagnosis of disease or other conditions. © 2022 Beckman Coulter, Inc. All rights reserved. Beckman Coulter, the stylized logo, and the Beckman Coulter product and service marks mentioned herein, including Biomek, are trademarks or registered trademarks of Beckman Coulter, Inc. in the United States and other countries. Echo and Access are trademarks or registered trademarks of Labcyte Inc. in the United States and other countries. Labcyte is a Beckman Coulter company. All other trademarks are the property of their respective owners.