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Unlike more common laboratory tests, the TissueCypher test uses an innovative spatialomics approach that combines immunofluorescence labeling, high-definition digital imaging, and artificial intelligence (AI). In this webinar, one of the architects behind TissueCypher, Dr. Rebecca Critchley-Thorne, walked through how the test works and what it means for management of BE. After the 20-minute presentation, she took questions from the audience and shared additional insights into the exciting field of precision medicine. 0:00 Introduction 1:57 Opening remarks 2:41 Clinical need in the management of Barrett's esophagus 3:27 Problems with management of non-dysplastic Barrett's esophagus 4:35 Unlocking the molecular and cellular signatures of BE progression 5:08 Understanding the spatialomics approach behind TissueCypher 5:44 Multiplexed labeling and imaging 8:43 Detection of cellular and tissue structures 9:53 Feature extraction and model building 12:43 Clinical validation 15:02 Use of TissueCypher in practice 19:17 Summary and conclusions 19:50 Question and answer session